|Catalog No||Formulation||Size||Price (USD)|
|249-MSM1-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|249-MSM1-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|249-MSM1-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||249|
|Human Gene Symbol||ALPL|
|Human Chromosome Location||1p36.12|
|Synonyms||Alkaline phosphatase, germ cell; Alkaline phosphatase, testicular and thymus; Alkaline phosphatase liver/bone/kidney; Alkaline phosphatase, tissue-nonspecific; ALPG; ALPL; Germ cell alkaline phosphatase; Testicular and thymus alkaline phosphatase; Tissue non-specific alkaline phosphatase; Tissue nonspecific ALP (TNAP or TNSALP)|
|Immunogen||Recombinant human ALPL protein|
|Host / Ig Isotype||Mouse / IgG1, kappa|
|Mol. Weight of Antigen||55kDa|
|Cellular Localization||Cell Surface|
|Species Reactivity||Human and Cow. Others not known.|
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (1:50-1:100 for 30 min at Room Temp)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.