|Catalog No||Formulation||Size||Price (USD)|
|250-MSM2-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|250-MSM2-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|250-MSM2-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||250|
|Human Gene Symbol||ALPP|
|Human Chromosome Location||2q37.1|
|Synonyms||Alkaline phosphatase placental type; Alkaline phosphatase Regan Isozyme; ALP; Alp1; ALPP; Germ-cell alkaline phosphatase; nagao Isozyme; PALP; Placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP-1; PLAP1|
|Immunogen||Recombinant full-length human ALPP protein|
|Host / Ig Isotype||Mouse / IgG2a, kappa|
|Mol. Weight of Antigen||70kDa|
|Cellular Localization||Cytoplasmic and cell surface|
|Species Reactivity||Human, Others not known.|
PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APs in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP as to AP from normal human testis. This MAb can be used both as coating as well as tracer antibody in the same ELISA to detect PLAP in serum of S, F, FS and I phenotypes.
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunohistology (Frozen) (1-2ug/ml for 30 minutes at RT)
Optimal dilution for a specific application should be determined.
HepG2 cells. Placenta or seminoma
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months. Non-hazardous. No MSDS required.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.