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Home >> Antibodies >> Parathyroid Hormone (PTH) (N-Terminal)

Parathyroid Hormone (PTH) (N-Terminal)

Recombinant Rabbit Monoclonal Antibody [Clone PTH/1717R]

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Catalog No Format Size Price (USD)
5741-RBM7-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
5741-RBM7-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 379.00
5741-RBM7-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 549.00
5741-RBM7-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 399.00
5741-RBM7-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 579.00
Human Entrez Gene ID 5741
Human SwissProt P01270
Human Unigene 37045
Human Gene Symbol PTH
Human Chromosome Location 11p15.3-p15.1
Synonyms hPTH; Parathormone; Parathyrin; Parathyroid hormone 1 (PTH1); Parathyroid hormone (PTH)
Immunogen Recombinant human PTH protein N-terminal fragment (exact sequence is proprietary)
Host / Ig Isotype Rabbit / IgG, kappa
Mol. Weight of Antigen 9kDa
Cellular Localization Cytoplasmic and Secreted
Species Reactivity Human. Others not known.
    

Specificity & Comments

Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (0.5-1ug/ml)
Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

Human parathyroid gland carcinoma

Supplied As

200ug/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Watson, P.H. and Hanley, D.A. 1993. Parathyroid hormone: regulation of synthesis and secretion. Clin. Invest. Med. 16: 58-77.
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