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Home >> Antibodies >> Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16

Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16

Recombinant Rabbit Monoclonal Antibody [Clone CDH16/1532R]

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Catalog No Format Size Price (USD)
1014-RBM2-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
1014-RBM2-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 379.00
1014-RBM2-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 549.00
1014-RBM2-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 399.00
1014-RBM2-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 579.00
Human Entrez Gene ID 1014
Human SwissProt O75309
Human Unigene 513660
Human Gene Symbol CDH16
Human Chromosome Location 16q22.1
Synonyms Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody
Immunogen Recombinant human full-length CDH16 protein
Host / Ig Isotype Rabbit / IgG, kappa
Mol. Weight of Antigen 130kDa
Cellular Localization Cell Surface with some cytoplasmic
Species Reactivity Human, Mouse and Rat. Others not known.
              

Specificity & Comments

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

Normal kidney or renal cell carcinoma.

Supplied As

200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40.
  2. Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28.
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