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Home >> Antibodies >> FSH-Receptor (Ovarian Marker)

FSH-Receptor (Ovarian Marker)

Mouse Monoclonal Antibody [Clone FSHR/1400]

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Catalog No Format Size Price (USD)
2492-MSM1-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 129.00
2492-MSM1-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 329.00
2492-MSM1-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 459.00
2492-MSM1-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 359.00
2492-MSM1-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 489.00
Human Entrez Gene ID 2492
Human SwissProt P23945
Human Unigene 1428
Human Gene Symbol FSHR
Human Chromosome Location 2p21-p16
Synonyms Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; FSHRO; LGR1; ODG1; ovarian dysgenesis 1
Immunogen Recombinant human full-length FSHR protein
Host / Ig Isotype Mouse / IgG1
Mol. Weight of Antigen 75kDa
Cellular Localization Cytoplasmic & Cell Surface
Species Reactivity Human. Others not known.
    

Specificity & Comments

Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, or 10mM Citrate buffer, pH6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

Uterine Carcinoma

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Beau, I., et al. 1998. The basolateral localization signal of the follicle-stimulating hormone receptor. J. Biol. Chem. 273: 18610-18616.
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