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Home >> Antibodies >> Catenin, alpha-1 (CTNNA1)

Catenin, alpha-1 (CTNNA1)

Mouse Monoclonal Antibody [Clone 1G5]

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Catalog No Formulation Size Price (USD)  
1495-MSM1-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 129.00
1495-MSM1-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 329.00
1495-MSM1-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 459.00
1495-MSM1-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 359.00
1495-MSM1-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 489.00
Human Entrez Gene ID 1495
Human SwissProt P35221
Human Unigene 445981
Human Gene Symbol CTNNA1
Human Chromosome Location 5q31.2
Synonyms Alpha E-catenin; Cadherin-associated protein; CAP102; Catenin alpha-1; CTNNA1; Renal carcinoma antigen NY-REN-13
Immunogen Human alpha catenin fusion protein
Host / Ig Isotype Mouse / IgG1
Mol. Weight of Antigen 102kDa
Cellular Localization Cell Surface
Species Reactivity Human. Others not known.

Specificity & Comments

Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, α-catenin forms a heterodimer with β-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.

Positive Control

HeLa, A431 or MCF-7 Cells

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


This antibody is available for research use only and is not approved for use in diagnosis.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Johnson, KR; Lewis, JE; Li, D; Wahl, J; Soler, AP; Knudsen, KA; Wheelock, MJ. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252-60
  2. Nieman, MT; Kim, JB; Johnson, KR; Wheelock, MJ. Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Science 1999, 112: 1621-32