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CD11b / MAC-1 (Microglial Marker)

Mouse Monoclonal Antibody [Clone ITGAM/271]

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Catalog No Formulation Size Price (USD)  
3684-MSM3-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 129.00
3684-MSM3-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 329.00
3684-MSM3-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 459.00
3684-MSM3-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 359.00
3684-MSM3-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 489.00
Human Entrez Gene ID 3684 (Human)
Human SwissProt P11215 (Human)
Human Unigene 172631 (Human)
Human Gene Symbol ITGAM
Human Chromosome Location 16p11.2
Synonyms CD11 antigen-like family member B; CD11b/CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A); Integrin alpha-M; Integrin beta 2 alpha subunit; ITGAM; Leukocyte adhesion receptor MO1; Ly-40; Mac-1a; MAC1; Mac1, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit
Immunogen Recombinant human ITGAM protein
Host / Ig Isotype Mouse / IgG1, kappa
Mol. Weight of Antigen 95kDa & 170kDa
Cellular Localization Cell surface
Species Reactivity Human, Others not known.

Specificity & Comments

CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin M combines with the Integrin ?2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin M/?2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.

Positive Control

Human monocytes & granulocytes. Human lymph nodes and tonsils.

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539.
  2. Ault K and Springer T. 1981. J. Immunol. 126:359.
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171.
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766.
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112.