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BRCA1 (Breast Marker)

Mouse Monoclonal Antibody [Clone BRCA1/1472]

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Catalog No Formulation Size Price (USD)  
672-MSM2-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 129.00
672-MSM2-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 329.00
672-MSM2-P2 Purified Ab with BSA and Azide at 200ug/ml 200 ug 459.00
672-MSM2-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 359.00
672-MSM2-P2ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 200 ug 489.00
Human Entrez Gene ID 672
Human SwissProt P38398
Human Unigene 194143
Human Gene Symbol BRCA1
Human Chromosome Location 17q21
Synonyms BRCA1; Breast and ovarian cancer susceptibility protein 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; PSCP; RING finger protein 53; RNF53
Immunogen Recombinant human BRCA1 protein fragment (aa445-620) (exact sequence is proprietary)
Host / Ig Isotype Mouse / IgG1
Mol. Weight of Antigen 220kDa
Cellular Localization Cytoplasmic and Nuclear
Species Reactivity Human. Others-not tested.

Specificity & Comments

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Known Applications & Suggested Dilutions

ELISA (For coating, order Ab without BSA)
Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Positive Control

A431 or HeLa Cells. Breast, Ovarian or Renal Cell Carcinoma

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


This antibody is available for research use only and is not approved for use in diagnosis.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Miki, Y., et al. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71.